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Downloads

Cr(VI) MOA Research Study data are freely available to registered users. The data are provided in the table below. Selecting “List all” will provide a complete list of all the data available. For each data download, there is a description of where the data were used, sorted by publication. Additionally, users may select “Original Data” to view unprocessed/ unaltered datasets from laboratories, etc., or “Manuscript Data” to view spreadsheets and related documents specific to analyses used for manuscripts. Users may also select a specific manuscript to view only the data associated with such (note: a list of the manuscripts is provided below the table).  All data are subject to the Cr(VI) MOA Study Privacy Policy, and users of the data have agreed to the Terms and Conditions.

 

Data Category Title Description Download
Original Data
Unpublished Data


Mouse 90 day
Rat 90 day
Pathology of SDD-treated Rodents in ACC-TS and NTP Studies This report includes the reviews of histologically-prepared duodenal specimens from studies in which F344/N rats and B6C3F1 mice were treated with varying doses of sodium dichromate dihydrate (SDD). (more…) Download
Manuscript Data


Iron Homeostasis
Iron Homeostasis Study Data Used in: Figures 1-4, Figure S1, and Table 2 from Suh et al. (2014), High concentrations of hexavalent chromium in drinking water alter iron homeostasis in F344 rats and B6C3F1 mice. Download
Manuscript Data


Micronucleus
7-day Micronucleus Study Used in: Figure 1F and Table 1 from Thompson et al. (2015), Duodenal crypt health following exposure to Cr(VI):  Micronucleus scoring γ-H2AX immunostaining, and synchrotron X-ray fluorescence microscopy. Download
Manuscript Data
Original Data


Synchrotron
Synchrotron Analysis of Rodent Duodenum

Used in: Figures 2E, 2F, 3D, S5 and Tables 1 and S4 in Thompson et al. (2015), Synchrotron-Based Imaging of Chromium and c-H2AX Immunostaining in the Duodenum Following Repeated Exposure to Cr(VI) in Drinking Water.

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Manuscript Data
Original Data


Big Blue®
Cr(VI) Big Blue® Rat Study Data Used in: Figure 1, Table 1 and Table 3 from Thompson et al. (2015), Assessment of the Mutagenic Potential of Cr(VI) in the Oral Mucosa of Big Blue Transgenic F344 Rats. Download
Manuscript Data
Original Data


Mouse Genomics
Rat and Mouse Genomics
QRT-PCR Genomics Data Used in:

  • Figures 3 and 6 from Kopec et al. (2012), Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water;
  • Figure 3, 9, and S5  from Kopec et al. (2012), Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.
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Original Data
Genomic Analysis Code Microarray Analysis SAS Templates and R P1(t) Calculation Scripts Download
Manuscript Data
Original Data


Ex Vivo Gastric Reduction
Rodent PBPK Models Used in: Figure 1 from Proctor et al. (2012), Hexavalent chromium reduction kinetics in rodent stomach contents  Download
Manuscript Data
Original Data


Ex Vivo Gastric Reduction
Human PBPK Models Used in: Figure 1 from Proctor et al. (2012), Hexavalent chromium reduction kinetics in rodent stomach contents 

 

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Mouse Protein Carbonyl Data Used in: Figure 2 from Thompson et al. (2011) Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium Download
Manuscript Data


Mouse 90 day
Total Cr in Scraped Duodenal Epithelium – Mouse Used in: Figure 4 from Thompson et al. (2011), Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium Download
Manuscript Data
Original Data


MOA Hypothesis 2011
Rodent PBPK
NTP 90-Day Study Used in:

  • Figure 1 from Kirman et al. (2012), Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium;
  • Figures 3 and S1 from Thompson et al. (2011), Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding Future Research: A Case Study Involving the Oral Carcinogenicity of Hexavalent Chromium
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Manuscript Data
Original Data


Risk Assessment
EPA IRIS External Review Draft: Hexavalent Chromium Table 2 from Thompson et al. (2013), A chronic oral reference dose for hexavalent chromium-induced intestinal cancer Download
Manuscript Data


Rat 90 day
Rat Glutathione Data Day 8 Used in:

  • Figure 9 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action
  • Figure 2 from Thompson et al. (2011),  Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium 
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Manuscript Data


Rat 90 day
Rat Glutathione Data Day 91 Figures 6, 7 and Table 6 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action Download
Manuscript Data


Rat 90 day
Total Cr in Scraped Duodenal Epithelium – Rat Used in:

  • Figure 4 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action
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Manuscript Data


Rat 90 day
Rat and Mouse Genomics
Rodent PBPK
Total Chromium in Rat Tissues Used in:

  • Figures 4 and 5 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action;
  • Table 2 from Kirman et al. (2012), Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium;  
  • Figure 10  from Kopec et al. (2012), Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.
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Manuscript Data


Mutation (K-Ras and Micronucleus)
Histopathology of the Mouse Duodenum and Scoring and Cr-DNA Binding Ex Vivo in Rat Used in: Supplementary data from O’Brien et al. (2013) Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water Download
Manuscript Data


Mutation (K-Ras and Micronucleus)
K-Ras codon 12 GGT to GAT mutation in murine duodenum Used in: Figure 3 from O’Brien et al. (2013) Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water Download
Manuscript Data


MOA Small Intestine 2013
Mouse Genomics
Rat 90 day
Mouse Glutathione Data Day 91 Used in:

  • Figure 2 and Table 4 from Thompson et al. (2011), Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium; 
  • Figure 6 from Kopec et al. (2012), Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water;
  • Figures 6, 7 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action;
  • Figures 5 and 9 from Thompson et al. (2013),  Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans

 

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Cr6Study Publications:

  • Ex Vivo Gastric Reduction – Proctor et al. (2012), Hexavalent chromium reduction kinetics in rodent stomach contents.
  • Cytotox/Genotox High Content Analysis – Thompson et al. (2012), Assessment of Cr(VI)-induced cytotoxicity and genotoxicity using high content analysis.
  • Human PBPK – Kirman et al. (2013), Physiologically based pharmacokinetic model for humans orally exposed to chromium.
  • MOA Hypothesis 2011 – Thompson et al. (2011), Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding Future Research: A Case Study Involving the Oral Carcinogenicity of Hexavalent Chromium.
  • MOA 2013 – Thompson et al. (2013), Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.
  • Mouse Genomics – Kopec et al. (2012), Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water.
  • Mutation (K-Ras and Micronucleus) – O’Brien et al. (2013), Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water.
  • Genotox Potential Cr(VI) – Thompson et al. (2012), Assessment of genotoxic potential of Cr(VI) in the mouse duodenum: An in silico comparison with mutagenic and nonmutagenic carcinogens across tissues.
  • Risk Assessment – Thompson et al. (2013), A chronic oral reference dose for hexavalent chromium-induced intestinal cancer.
  • Rat 90 Day – Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action.
  • Rat and Mouse Genomics – Kopec et al. (2012), Comparative toxicogenomic analysis of oral Cr(VI) exposure effects in rat and mouse small intestinal epithelia.
  • Rodent PBPK – Kirman et al. (2012), Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium.