Blog Archives

NTP 90-Day Study

Used in: Figure 1 from Kirman et al. (2012), Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium; Figures 3 and S1 from Thompson et al. (2011), Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding … Continue reading

Comments Off on NTP 90-Day Study

EPA IRIS External Review Draft: Hexavalent Chromium

Table 2 from Thompson et al. (2013), A chronic oral reference dose for hexavalent chromium-induced intestinal cancer

Comments Off on EPA IRIS External Review Draft: Hexavalent Chromium

Rat Glutathione Data Day 8

Used in: Figure 9 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action Figure 2 from Thompson et al. … Continue reading

Comments Off on Rat Glutathione Data Day 8

Rat Glutathione Data Day 91

Figures 6, 7 and Table 6 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action

Comments Off on Rat Glutathione Data Day 91

Total Cr in Scraped Duodenal Epithelium – Rat

Used in: Figure 4 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action

Comments Off on Total Cr in Scraped Duodenal Epithelium – Rat

Total Chromium in Rat Tissues

Used in: Figures 4 and 5 from Thompson et al. (2012), Comparison of the Effects of Hexavalent Chromium in the Alimentary Canal of F344 Rats and B6C3F1 Mice Following Exposure in Drinking Water: Implications for Carcinogenic Modes of Action; Table 2 from Kirman et … Continue reading

Comments Off on Total Chromium in Rat Tissues

Histopathology of the Mouse Duodenum and Scoring and Cr-DNA Binding Ex Vivo in Rat

Used in: Supplementary data from O’Brien et al. (2013) Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water

Comments Off on Histopathology of the Mouse Duodenum and Scoring and Cr-DNA Binding Ex Vivo in Rat

K-Ras codon 12 GGT to GAT mutation in murine duodenum

Used in: Figure 3 from O’Brien et al. (2013) Assessment of K-Ras mutant frequency and micronucleus incidence in the mouse duodenum following 90-days of exposure to Cr(VI) in drinking water

Comments Off on K-Ras codon 12 GGT to GAT mutation in murine duodenum

Mouse Glutathione Data Day 91

Used in: Figure 2 and Table 4 from Thompson et al. (2011), Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium;  Figure 6 from Kopec et al. (2012), Genome-wide gene expression effects in B6C3F1 … Continue reading

Comments Off on Mouse Glutathione Data Day 91

Mouse Glutathione Data Day 8

Used in: Figure 2 and Table 3 from Thompson et al. (2011) Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium; Figure 5 from Thompson et al. (2013), Assessment of the mode of action underlying … Continue reading

Comments Off on Mouse Glutathione Data Day 8