Blog Archives

Pathology of SDD-treated Rodents in ACC-TS and NTP Studies

This report includes the reviews of histologically-prepared duodenal specimens from studies in which F344/N rats and B6C3F1 mice were treated with varying doses of sodium dichromate dihydrate (SDD).

Comments Off on Pathology of SDD-treated Rodents in ACC-TS and NTP Studies

Synchrotron Analysis of Rodent Duodenum

Used in: Figures 2E, 2F, 3D, S5 and Tables 1 and S4 in Thompson et al. (2015), Synchrotron-Based Imaging of Chromium and c-H2AX Immunostaining in the Duodenum Following Repeated Exposure to Cr(VI) in Drinking Water.

Comments Off on Synchrotron Analysis of Rodent Duodenum

Cr(VI) Big Blue® Rat Study Data

Used in: Figure 1, Table 1 and Table 3 from Thompson et al. (2015), Assessment of the Mutagenic Potential of Cr(VI) in the Oral Mucosa of Big Blue Transgenic F344 Rats.

Comments Off on Cr(VI) Big Blue® Rat Study Data

QRT-PCR Genomics Data

Used in: Figures 3 and 6 from Kopec et al. (2012), Genome-wide gene expression effects in B6C3F1 mouse intestinal epithelia following 7 and 90 days of exposure to hexavalent chromium in drinking water; Figure 3, 9, and S5  from Kopec et al. (2012), … Continue reading

Comments Off on QRT-PCR Genomics Data

Rodent PBPK Models

Used in: Figure 1 from Proctor et al. (2012), Hexavalent chromium reduction kinetics in rodent stomach contents 

Comments Off on Rodent PBPK Models

Human PBPK Models

Used in: Figure 1 from Proctor et al. (2012), Hexavalent chromium reduction kinetics in rodent stomach contents   

Comments Off on Human PBPK Models

NTP 90-Day Study

Used in: Figure 1 from Kirman et al. (2012), Physiologically based pharmacokinetic model for rats and mice orally exposed to chromium; Figures 3 and S1 from Thompson et al. (2011), Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding … Continue reading

Comments Off on NTP 90-Day Study

EPA IRIS External Review Draft: Hexavalent Chromium

Table 2 from Thompson et al. (2013), A chronic oral reference dose for hexavalent chromium-induced intestinal cancer

Comments Off on EPA IRIS External Review Draft: Hexavalent Chromium

NTP 2-year Study

Used in: Figures 4, 6, and Tables 1, 2 from Thompson et al. (2011), Application of the U.S. EPA Mode of Action Framework for Purposes of Guiding Future Research: A Case Study Involving the Oral Carcinogenicity of Hexavalent Chromium; Figures 1, 4, 5, … Continue reading

Comments Off on NTP 2-year Study

Raw Unprocessed Genomics Data

Both the raw unprocessed genomics data and metadata can be obtained by following the “download” link to the right and downloading from a secure Dropbox location.

Comments Off on Raw Unprocessed Genomics Data