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Cr(VI) MOA Study Presentations

Findings of the Cr(VI) Mode of Action (MOA) Research Study have been presented at several scientific conferences including annual meetings of the Society of Toxicology and the Toxicology Forum. These presentations focus on the potential effects of hexavalent chromium exposure in both rodents and humans, particularly the risk of cancerous tumor formations following ingestion from sources such as drinking water.

2017

Kirman CR, Proctor D, Suh M, Haws L, Harris M, Thompson C, Hays S. Using physiologically-based pharmacokinetic modeling to address potentially sensitive subpopulations exposure to hexavalent chromium. Poster presented at Society of Toxicology Annual Meeting. March 15, 2017. Baltimore, MD.

Rager JE, Thompson CM, Ring C, Fry RC, Harris MA. Integration of transcriptomics and high-throughput screening predictions with robust in vivo data to inform hexavalent chromium mode of action. Poster presented at Society of Toxicology Annual Meeting. March 14, 2017. Baltimore, MD.

Suh M, Harvey S, Wikoff D, Mittal L, Ring C, Goodmanson A, Proctor D. Meta-analysis of hexavalent chromium and stomach cancer. Poster presented at Society of Toxicology Annual Meeting. March 13, 2017. Baltimore, MD.

Thompson C, Kirman C, Suh M, Proctor D, Haws L, Harris M, Hays S. Risk assessment of oral exposure to Cr(VI): Integration of mode of action, pharmacokinetics, and dose-response modeling. Poster presented at Society of Toxicology Annual Meeting. March 14, 2017. Baltimore, MD.

Thompson C, Rager J, Suh M, Proctor D, Haws L, Harris M. Mechanistic support for nonlinear risk assessment of rat oral cavity tumors induced by exposure to Cr(VI) in drinking water. Poster presented at Society of Toxicology Annual Meeting. March 15, 2017. Baltimore, MD.

2016

Rager J. 2016. Integration of High-Content and High-Throughput Screening Data to Inform Hexavalent Chromium Mode of Action. Environmental Mutagenesis and Genomics Society. September 26, 2016. Kansas City, KS. 

CM Thompson, M Suh, DM Proctor, JE Rager, LC Haws, and MA Harris. Assessment of the In Vivo Genotoxicity of CrVI in Target Organs Identified in a Two-year Cancer Bioassay. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

JM Cullen, JM Ward, and CM Thompson. 2016. Re-Evaluation and Classification of Duodenal Lesions in B6C3F1 Mice and F344 Rats from Four Studies of Hexavalent Chromium in Drinking Water. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

CM Thompson. 2016. Non-mutagenic MOA for Cr(VI) involving intestinal cytotoxicity and regenerative hyperplasia. Platform presentation in the “The Cancer Risk Assessment for Ingested Hexavalent Chromium: Challenges and Controversies” Session. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

Proctor DM. 2016. Cancer Risk Assessment for Ingested Hexavalent Chromium:  Challenges and Controversies – Introduction. Presented at the Society of Toxicology’s 55th Annual Meeting, March 13-17, 2016. New Orleans, LA.

2015

CM Thompson, RR Young, M Suh, H Dinesdurage, R Elbekai, MA Harris, AC Rohr, and D Proctor. Hexavalent Chromium Does Not Induce Mutations in the Oral Mucosa of Transgenic Big Blue© Rats Following Drinking Water Exposures at a Carcinogenic Dose. Presented at the Society of Toxicology’s 54th Annual Meeting,  March 22-26, 2015, San Diego, CA.

MA Harris, CM Thompson, D Proctor, M Suh, J Wolf, J Seiter, M Chappell, and LC Haws. Analysis of Duodenal Crypt Health Following Exposure to Cr(VI) in Drinking Water. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, 2015, San Diego, CA.

CR Kirman, D Proctor, M Suh, and S Hays. Reduction of Hexavalent Chromium by Gastric Fluids from Fed and Fasted Individuals with Applications to Toxicokinetic Modeling. Presented at the Society of Toxicology’s 54th Annual Meeting, March 22-26, 2015, San Diego, CA.

 2014

C. Thompson. Update on hexavalent chromium cancer mode of action.    Triservices Environmental Risk Assessment Working Group, Winter Meeting.  Feb. 25, 2014, San Antonio, TX.

C.M. Thompson, D. Proctor, M. Suh, J. Wolf, L.C. Haws, M.A. Harris.  X-Ray Fluorescence Microspectroscopic Analysis of Duodenal Mucosae following Cr(VI) Exposure in Drinking Water.  Presented at the Society of Toxicology’s 53rd Annual Meeting, March 24-27, 2014. Phoenix, AZ.

S.M. Hays, C.R. Kirman, M. Suh, D. Proctor.  Gastric Reduction of Hexavalent Chromium in Fed and Fasted Human Stomach Samples.   Presented at the Society of Toxicology’s 53rd Annual Meeting, March 24-27, 2014. Phoenix, AZ.

C.R. Kirman, D. Proctor, M. Suh, C.M. Thompson, M.A. Harris, L.C. Haws, S.M. Hays. Variation Analysis of PBPK Model Parameters for Describing the Delivery of Cr(VI) to the Small Intestines of Humans.  Presented at the Society of Toxicology’s 53rd Annual Meeting, March 24-27, 2014. Phoenix, AZ.

2013

Suh, M, Thompson, C.M., Hixon, J.G., Harris, M.A., Kirman, C.R., Hays, S, Haws, L.C., Proctor, D.M. Potential Involvment of Oxidative Stress and Iron Disturbance in the Development of Oral Cavity Tumors in Rats Exposed to Hexavalent Chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, 2013. San Antonio, TX.

Thompson, C.M., Kirman, C.R., Proctor, D.M., Suh, M., Hays, S.M., Haws, L.C., Harris, M.A. A Chronic Oral Reference Dose for Hexavalent Chromium. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, 2013. San Antonio, TX.

Proctor, D.M., Suh, M., Thompson, C.M., Harris, M.A. Mode of action evaluation for hexavalent chromium-induced lung cancer. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, 2013. San Antonio, TX.

Kirman, C.R., Thompson, C.M., Proctor, D.M., Suh, M., Haws, L.C., Harris, M.A., Hays, S.M. Using PBPK Modeling to Address Diurnal Variation and Age Differences in Hexavalent Chromium Toxicokinetics in Humans. Presented at the Society of Toxicology’s 52nd Annual Meeting, March 10-14, 2013. San Antonio, TX.

2012

Genome-Wide Gene Expression Analysis of Cr(VI) Effects in Fisher Rat Small Intestinal Epithelium.  S. Kim; A. K. Kopec; A. L. Forgacs; C. M. Thompson; T. R. Zacharewski.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Assessment of Genotoxic Potential of Cr(VI) in the Mouse Duodenum via Toxicogenomic Profiling.  C. M. Thompson; J. G. Hixon; A. K. Kopec; M. A. Harris; D. M. Proctor; L. C. Haws.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Comparative Toxicogenomic Analysis of Cr(VI) Effects in Rat and Mouse Small Intestine.  A. K. Kopec; A. L. Forgacs; S. Kim; C. M. Thompson; T. R. Zacharewski.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Mode of Action for Intestinal Carcinogenesis of Ingested Hexavalent Chromium in Mice.  D. Proctor; C. M. Thompson; M. Suh; L. C. Haws; M. A. Harris.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Physiologically-Based Pharmacokinetic Model for Mice, Rats and Humans Orally-Exposed to Chromium.  C. R. Kirman; S. M. Hays; L. L. Aylward; M. Suh; D. Proctor.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Gastric Reduction of Cr(VI) in Mice, Rats and Humans.  S. M. Hays; C. Kirman; L. Aylward; M. Suh; D. Proctor.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Assessment of Genotoxic Potential of Cr(VI) in the Intestine via In Vivo Intestinal Micronucleus Assay and In Vitro High Content Analysis in Differentiated and Undifferentiated Caco-2.  M. A. Harris; C. M. Thompson; J. C. Wolf; Y. Fedorov; J. G. Hixon; D. M. Proctor; M. Suh; L. C. Haws.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

K-ras codon 12 GGT to GAT mutation is not elevated in the duodenum of mice subchronically exposed to hexavalent chromium in drinking water.  T. J. O’Brien; D. Hao; M. Suh; D. Proctor; C. M. Thompson; M. A. Harris; B. L. Parsons; M. B. Meyers.  Presented at the Society of Toxicology’s 51st Annual Meeting, March 11-15, 2012. San Francisco, CA.

Overview of the hexavalent chromium mode of action research project.  L. Haws, Thompson, C., Proctor, D., Suh, M., Harris.    Presented at the 37th Annual Winter Meeting of The Toxicology Forum, January 31-February 2, 2012. Washington, D.C.

2011

Workshop:  Using mode of action data to guide quantitative cancer risk assessment:  A case study of hexavalent chromium in drinking water.  D. Proctor and B. Meek.  Presented at the Society of Toxicology’s 5oth Annual Meeting, March 6-10, 2011. Washington, DC.

Research plan to fill data gaps in the mode of action for cancer risk assessment of hexavalent chromium in drinking water. Haws. L., D. Proctor, C. Thompson, and M. Harris. Presented at the Society of Toxicology’s 5oth Annual Meeting, March 6-10, 2011. Washington, DC.

Use of mode of action and pharmacokinetic findings to inform the cancer risk assessment of ingested Cr(VI):  A case study.  D. Proctor, L. Haws, C. Thompson and M. Harris.  Presented at the Society of Toxicology’s 5oth Annual Meeting, March 6-10, 2011. Washington, DC.

Comparison of basal and Cr(VI)-mediated solute carrier gene expression in rodent duodenal epithelium.  S. Kim, C. Thompson, A, Kopec, M. Harris and T. Zacharewski.   Presented at the Society of Toxicology’s 5oth Annual Meeting, March 6-10, 2011. Washington, DC.

2010

Mode of action for cancer risk assessment of ingesting hexavalent chromium: identifying and resolving data gaps.  C. Thompson, D. Proctor, L. Haws and M. Harris.  Presented at the Society of Toxicology’s 49th Annual Meeting, March 7-11, 2010. Salt Lake City, Utah.